LDL

From studies of patients with hard end points. Death. So this section looks at the data and conclusions that indicate that your chances of dying go up when your cholesterol goes down!

LDL studies

“If you have high cholesterol it appears you are likely to live longer than those with low cholesterol”

Study 1.

Association between low density lipoprotein (LDL) cholesterol and all-cause mortality: results from the NHANES 1999–2014

https://www.nature.com/articles/s41598-021-01738-w

LDL studies

If you have high cholesterol it appears you are likely to live longer than those with low cholesterol

Study 1 continued...

Association between low density lipoprotein cholesterol and all-cause mortality: results from the NHANES 1999–2014

A systematic review in 2016 looked at 19 cohort studies with over 68,000 participants. 16 of them found an inverse relationship between LDL cholesterol and all cause mortality. That means the higher your LDL cholesterol the lower your chance of dying from any cause.

The study is entitled

Lack of an association or an inverse association between low-density-lipoprotein cholesterol and mortality in the elderly: a systematic review

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4908872/

Cholesterol is essential for life.

Having high HDL combined with low triglycerides is a much better predictor of longevity and reduced risks of heart conditions than LDL levels

Study 2 title

Low triglycerides-high high-density lipoprotein cholesterol and risk of ischemic heart disease

https://pubmed.ncbi.nlm.nih.gov/11176761/

Conclusion: Men with conventional risk factors for Ischemic Heart Disease have a low risk of IHD if they have low TG combined with high HDL-C levels

Study 3 (men only in the study)

High triglycerides/low high-density lipoprotein cholesterol, ischemic electrocardiogram changes, and risk of ischemic heart disease

https://pubmed.ncbi.nlm.nih.gov/12514661/

Conclusions: In men free of clinical IHD, ischemic ECG changes were significantly more predictive of fatal IHD in men with high TG/low HDL-C, indicating an adverse synergistic effect of these 2 risk factors

Study 4 (women only in the study)

Triglycerides + high-density-lipoprotein-cholesterol dyslipidemia, a coronary risk factor in elderly women

https://pubmed.ncbi.nlm.nih.gov/16207260/

Conclusions: TG and HDL-C were independent predictors of CHD mortality in elderly women. The combination of high TG + low HDL-C quadrupled the risk of CHD mortality in this gender only.